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Question 11
•Which of the following statements regarding lactic acidosis is FALSE?
A.It is an uncommon cause of metabolic acidosis
B.The source of elevated lactic acid comes from the conversion of pyruvate to lactate
C.In anoxic states, the cellular lack of NAD prevents mitochondrial reduction of lactate to pyruvate
D.Lactic acidosis caused by tissue hypoxia is classified as type A lactic acidosis
E.Liver and kidney gluconeogenesis contribute significantly to lactate utilization
Answer & Comments
•A
•Comments:
–Lactic acidosis
•Lactic acidosis is the most common cause of metabolic acidosis.
•Lactate is produced in the anaerobic glycolysis pathway.
•Normally, physiologic levels of lactate are cleared through gluconeogenesis in the kidney and liver.
•When this system is overwhelmed and NAD is lacking, lactate levels rise.
•This commonly occurs in hypoxic or hypovolemic states and is referred to as type A lactic acidosis.
•Which of the following statements regarding lactic acidosis is FALSE?
A.It is an uncommon cause of metabolic acidosis
B.The source of elevated lactic acid comes from the conversion of pyruvate to lactate
C.In anoxic states, the cellular lack of NAD prevents mitochondrial reduction of lactate to pyruvate
D.Lactic acidosis caused by tissue hypoxia is classified as type A lactic acidosis
E.Liver and kidney gluconeogenesis contribute significantly to lactate utilization
Answer & Comments
•A
•Comments:
–Lactic acidosis
•Lactic acidosis is the most common cause of metabolic acidosis.
•Lactate is produced in the anaerobic glycolysis pathway.
•Normally, physiologic levels of lactate are cleared through gluconeogenesis in the kidney and liver.
•When this system is overwhelmed and NAD is lacking, lactate levels rise.
•This commonly occurs in hypoxic or hypovolemic states and is referred to as type A lactic acidosis.
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