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Question 1
•Syndrome of inappropriate antidiuretic hormone (SIADH) secretion can be caused by each of the following EXCEPT
A.Meningitis
B.Pneumonia
C.Hyperthryoidism
D.Thiazide diuretics
E.Monoamine oxidase inhibitors
Answer & Comments
•C
•Comments:
–The diagnosis of SIADH is primarily one of exclusion that should be made in the absence of hypovolemia, hypervolemia, renal failure, and drugs that impair water excretion.
–The causes of this syndrome are diverse, ranging from central nervous system disorders and tumors (lung cancer, lymphoma, thymoma) to pulmonary and endocrine disorders, including glucocorticoid insufficiency and hypothyroidism.
–There are miscellaneous causes such as porphyria, pain, and nausea.
–Opiates, chlorpropamide, NSAIDs, cyclophosphamide,
phenothiazines, MAO inhibitors, tricyclic antidepressants, and thiazide diuretics are among the drugs that have been implicated in this syndrome.
•Syndrome of inappropriate antidiuretic hormone (SIADH) secretion can be caused by each of the following EXCEPT
A.Meningitis
B.Pneumonia
C.Hyperthryoidism
D.Thiazide diuretics
E.Monoamine oxidase inhibitors
Answer & Comments
•C
•Comments:
–The diagnosis of SIADH is primarily one of exclusion that should be made in the absence of hypovolemia, hypervolemia, renal failure, and drugs that impair water excretion.
–The causes of this syndrome are diverse, ranging from central nervous system disorders and tumors (lung cancer, lymphoma, thymoma) to pulmonary and endocrine disorders, including glucocorticoid insufficiency and hypothyroidism.
–There are miscellaneous causes such as porphyria, pain, and nausea.
–Opiates, chlorpropamide, NSAIDs, cyclophosphamide,
phenothiazines, MAO inhibitors, tricyclic antidepressants, and thiazide diuretics are among the drugs that have been implicated in this syndrome.
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